After earning his diploma in Electronics and Telecommunications Engineering in 2000 in Turin, Italy, Puglisi moved to London to study English and web design. In 2002 he moved back to Italy where he started to work for CUNA, the Italian standardisation body for road vehicles.
He became involved as Italian representative in ISO and CEN standardisation activities in automotive electronics, lighting, and telematics; active and passive safety; ergonomics, and visibility.
Aside from his standardisation work, since 2004 he has managed the GTB secretariat. His GTB work has increased significantly over the years, and in 2018 he left CUNA to devote full-time effort to GTB in his new position as Secretary-General.
That same year, he graduated in Political Science and International Relations with a thesis on geopolitical and geo-economic impacts deriving from the electrification of the automotive sector.
In addition to his core GTB duties, he is the secretary of the GRE Informal Working Group on the Simplification of the UN Lighting and Light Signalling Regulations (SLR) since its establishment in 2014.